                         SEQUENCE LISTING

<110>  Santaris Pharma A/S
 
<120>  Potent anti APOB antisense compounds

<130>  1087WO

<140>  61/186,388
<141>  2010-06-10

<150>  61/186,388
<151>  2009-06-12

<160>  51    

<170>  PatentIn version 3.3

<210>  1
<211>  14
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<400>  1
tctgaagtcc atga                                                       14


<210>  2
<211>  14
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<400>  2
ggatcaaata taag                                                       14


<210>  3
<211>  14
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<400>  3
gttgacactg tctg                                                       14


<210>  4
<211>  12
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<400>  4
gttgacactg tc                                                         12


<210>  5
<211>  14
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<400>  5
gactgcctgt tctc                                                       14


<210>  6
<211>  13
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<400>  6
cgttggagta agc                                                        13


<210>  7
<211>  14
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<400>  7
gcgttggagt aagc                                                       14


<210>  8
<211>  14
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<400>  8
ctctgtgatc cagg                                                       14


<210>  9
<211>  14
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<400>  9
ggactctgtg atcc                                                       14


<210>  10
<211>  14
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<400>  10
ctgtttgagg gact                                                       14


<210>  11
<211>  14
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<400>  11
gagatggcag atgg                                                       14


<210>  12
<211>  14
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<400>  12
gctggtgttg ccac                                                       14


<210>  13
<211>  13
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<400>  13
cagatccttg cac                                                        13


<210>  14
<211>  14
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<400>  14
ccagatcctt gcac                                                       14


<210>  15
<211>  12
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<400>  15
accttttgag ac                                                         12


<210>  16
<211>  14
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<400>  16
caatgttcag actg                                                       14


<210>  17
<211>  14
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<400>  17
cctgcaatgt tcag                                                       14


<210>  18
<211>  14
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<400>  18
tagggctgta gctg                                                       14


<210>  19
<211>  14
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<400>  19
gttggtctac ttca                                                       14


<210>  20
<211>  14
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<400>  20
ccaaccaatt tctc                                                       14


<210>  21
<211>  14
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<400>  21
gtcaattgta aagg                                                       14


<210>  22
<211>  14
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<400>  22
gtttaagaaa tcca                                                       14


<210>  23
<211>  12
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<400>  23
cttagtgtta gc                                                         12


<210>  24
<211>  12
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<400>  24
ggttcttagt gt                                                         12


<210>  25
<211>  14
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<400>  25
ctggttctta gtgt                                                       14


<210>  26
<211>  14
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  Phosphorothioate

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<400>  26
tctgaagtcc atga                                                       14


<210>  27
<211>  14
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  phosphorothioate

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<400>  27
ggatcaaata taag                                                       14


<210>  28
<211>  14
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  phosphorothioate

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<400>  28
gttgacactg tctg                                                       14


<210>  29
<211>  12
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  phosphorothioate

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<400>  29
GTTGACACTG TC                                                       14


<210>  30
<211>  14
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  phosphorothioate

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<400>  30
gactgcctgt tctc                                                       14


<210>  31
<211>  13
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  phosphorothioate

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<400>  31
cgttggagta agc                                                        13


<210>  32
<211>  14
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  phosphorothioate

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<400>  32
gcgttggagt aagc                                                       14


<210>  33
<211>  14
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  phosphorothioate

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<400>  33
ctctgtgatc cagg                                                       14


<210>  34
<211>  14
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  phosphorothioate

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<400>  34
ggactctgtg atcc                                                       14


<210>  35
<211>  14
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  phosphorothioate

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<400>  35
ctgtttgagg gact                                                       14


<210>  36
<211>  14
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  phosphorothioate

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<400>  36
gagatggcag atgg                                                       14


<210>  37
<211>  14
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  phosphorothioate

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<400>  37
gctggtgttg ccac                                                       14


<210>  38
<211>  13
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  phosphorothioate

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<400>  38
cagatccttg cac                                                        13


<210>  39
<211>  14
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  phosphorothioate

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<400>  39
ccagatcctt gcac                                                       14


<210>  40
<211>  12
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  phosphorothioate

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<400>  40
gttgacactg tc                                                         12


<210>  41
<211>  12
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  phosphorothioate

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<400>  41
accttttgag ac                                                         12


<210>  42
<211>  14
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  phosphorothioate

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<400>  42
cctgcaatgt tcag                                                       14


<210>  43
<211>  14
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  phosphorothioate

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<400>  43
tagggctgta gctg                                                       14


<210>  44
<211>  14
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  phosphorothioate

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<400>  44
gttggtctac ttca                                                       14


<210>  45
<211>  14
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  phosphorothioate

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<400>  45
ccaaccaatt tctc                                                       14


<210>  46
<211>  14
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  phosphorothioate

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<400>  46
gtcaattgta aagg                                                       14


<210>  47
<211>  14
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  phosphorothioate

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<400>  47
gtttaagaaa tcca                                                       14


<210>  48
<211>  12
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  phosphorothioate

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<400>  48
cttagtgtta gc                                                         12


<210>  49
<211>  12
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  phosphorothioate

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<400>  49
ggttcttagt gt                                                         12


<210>  50
<211>  14
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  phosphorothioate

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  LNA, preferably beta-D oxy LNA, LNA Cs preferably 5-methyl C

<400>  50
ctggttctta gtgt                                                       14


<210>  51
<211>  13
<212>  DNA
<213>  Artificial

<220>
<223>  Oligo sequence motif or oligomeric compound

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  phosphorothioate

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  beta-D oxy LNA

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  beta-D oxy LNA

<400>  51
gcattggtat tca                                                        13


